Minnesota LB Anthony Barr's 27-yard return of TE Austin Seferian-Jenkins' fumble on the first play of overtime handed the Bucs their sixth loss of the season and dropped their record to 1-6.
Jenkins previously helped put the Bucs ahead with 2:02 left in regulation when he hauled in a seven-yard touchdown pass from QB Mike Glennon.
Glennon finished the game completing 19 of 28 passes for one touchdown and one interception.
WR Mike Evans led all receivers with 78 yards on four catches.
LB Lavonte David continued his solid play, notching 14 tackles, while DT Gerald McCoy, just one day removed from signing a new seven-year deal with the Bucs, recorded a half a sack.
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Photos from the first half of Buccaneers vs. Vikings at Raymond James Stadium.
Photos from the second half of Buccaneers vs. Vikings at Raymond James Stadium.